Molecular characterization and biological activity of bovine interferon-omega3

D An, Y Guo, J Bao, X Luo, Y Liu, B Ma, M Gao… - Research in veterinary …, 2017 - Elsevier
… a potential as a novel antiviral therapeutic agent, exerts antiviral activity against VSV in …
against bovine virus that including BEV, IBRV and BVDV. In this study, we present a novel type I …

Design, biological activity and signaling pathway of bovine consensus omega interferon expressed in Pichia pastoris

M Gao, Y Guo, X Luo, J Du, Y Wang, C Cao… - Molecular …, 2019 - Elsevier
… Therefore, a consensus BoIFN-ω (CoBoIFN-ω) was designed and characterized in this
study, and was demonstrated to have antiviral and antiproliferative activities, transduce signals …

[HTML][HTML] A novel type-I interferon family, bovine interferon-chi, is involved in positive-feedback regulation of interferon production

Y Guo, Z Song, C Li, Y Yu, H Dai, X Luo… - Frontiers in …, 2020 - frontiersin.org
… on the bovine genome (5). Here, we characterize and measure the activity and regulation of
… have the typical molecular characteristics of type-I IFNs; exhibit antiviral and antiproliferative …

Cloning, prokaryotic soluble expression, and analysis of antiviral activity of two novel feline IFN-ω proteins

X Wang, F Li, M Han, S Jia, L Wang, X Qiao, Y Jiang… - Viruses, 2020 - mdpi.com
activity in Vero, F81 (feline kidney cell), Madin–Darby bovine … -species antiviral activity than
the INTERCAT IFN antiviral drug… Homology and phylogenetic tree analysis of the feline IFN-ω …

Characterization and signaling pathway analysis of interferon-kappa in bovine

Y Guo, D An, Y Liu, J Bao, X Luo, X Cheng… - Developmental & …, 2017 - Elsevier
… This study reported the identification and characterization of bovine IFN-κ, including its
antiviral activity and signaling pathway. BoIFN-ε and BoIFN-β contain a signal peptide of 21 …

Interferon-omega: Current status in clinical applications

S Li, F Zhao, J Shao, Y Xie, H Chang… - International …, 2017 - Elsevier
… We provide a broad knowledge of the characteristics and biological functions of IFN-ω. …
antiviral activities after being treated with 0.25% trypsin. However, it retains high antiviral activity

[HTML][HTML] Cross-species genome-wide analysis reveals molecular and functional diversity of the unconventional interferon-ω subtype

LE Shields, J Jennings, Q Liu, J Lee, W Ma… - Frontiers in …, 2019 - frontiersin.org
… their antiviral and inflammatory regulation, we characterized … -ω subtype has evolved several
novel features, which include: … that have much higher antiviral potency than typical IFN-α (14…

Identification and characterization of a rabbit novel IFN-α unlocated in genome

M Gao, Y Liu, Y Guo, Y Wang, H Dai, Z Song… - Developmental & …, 2018 - Elsevier
… A novel rabbit IFN-α gene named RbIFN-αNov1 was amplified from rabbit genomic …
characterized in this study. Our results showed that RbIFN-αNov1 exhibits significant antiviral activity

Synthetic RNA derived from the foot-and-mouth disease virus genome elicits antiviral responses in bovine and porcine cells through IRF3 activation

MR Pulido, L Del Amo, F Sobrino, M Sáiz - Veterinary microbiology, 2018 - Elsevier
… Then, aliquots of 500 ng RNA were used for RT-PCR analysis. Previously reported primers
… Next, we sought to test the autocrine and paracrine antiviral effects of the 3NCR on bovine

Interferon-beta, interferon-gamma and their fusion interferon of Siberian tigers (Panthera tigris altaica) in China are involved in positive-feedback regulation of …

M Mu, H Zhao, Y Wang, M Guo, X Nie, Y Liu… - Developmental & …, 2021 - Elsevier
… in this analysis. The … their characterization and biological activity. Compared with PtIFN-β
and PtIFN-γ, PtIFNβ-γ has stronger antiviral activity and stable physicochemical characteristics